Postdoctoral Fellow - Single Molecule Biophysics Super-resolution Microscopy of Protein Dynamics

All UK vacanciesAcademic or ResearchPostdoctoral Fellow - Single Molecule Biophysics Super-resolution Microscopy of Protein Dynamics

Biological Sciences,Biology,Molecular Biology and Biophysics,Other Biological Sciences,Computer Science,Computer Science

Short info about job

Company: European Molecular Biology Laboratory (EMBL)

Salary: Not specified

Hours: Full Time

Contract type: Fixed-Term/Contract

Type / Role: Academic or Research

Phone: +44-1322 6790069

Fax: +44-1431 3022583

E-mail: N\A

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Detail information about job Postdoctoral Fellow - Single Molecule Biophysics Super-resolution Microscopy of Protein Dynamics. Terms and conditions vacancy

Contract Duration: Initially 3 years

Job DescriptionThe European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Barcelona (Spain), Grenoble (France), Hamburg (Germany), Hinxton near Cambridge (UK) and Rome (Italy).

In higher eukaryotes, proteins that lack apparent folded structure are enriched in many vital processes. The group of Dr. Lemke at the EMBL studies interactions between intrinsically disordered proteins and structured proteins in vital cellular processes, such as nuclear transport. Since such highly dynamic systems are inaccessible by most conventional approaches, the group applies a multidisciplinary approach combining single molecule, microfluidics and super-resolution techniques with chemical biology tools.

As part of the 5 year ERC funded ERC project “Next generation Single Molecule Protein Fluorescence” we are now looking for a postdoctoral fellow with a strong interest in further expanding quantitative single molecule technologies to understand the molecular mechanisms of IDPs. Furthermore, we aim to address fundamental limitations of single molecule spectroscopy and microscopy with respect to working on complex biological questions, using new technology development in microfluidics.

The project is ideally suited for candidates with a strong background in the physical sciences, such as advanced fluorescence techniques or other instrumentation heavy disciplines. Previous experience in programming, ideally in Labview will be seen as a major advantage. Experience in biochemistry and/or mammalian cell culture and respective microscopy is helpful. However, most important is an interdisciplinary interest and the ability or to tackle a biological problem with a combination of techniques, ranging from sample preparation via measurements on custom-built equipment to advanced computational analysis. A general strong interest in quantitative approaches towards biological problems is essential. Since EMBL offers excellent training in various aspects of these research topics, high interest and motivation are the main selection criteria and candidates from other disciplines that want to venture into these areas are explicitly welcome to apply.

The group of Dr. Lemke is embedded into the Structural and Computational Biology as well as the Cell Biology and Biophysics Units at the EMBL, offering a large range of groups spanning various techniques from the molecular to the systems level. Applicants should feel comfortable to work in such an interdisciplinary and international environment.

ReferencesDecoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6342-E6351

Debugging Eukaryotic Genetic Code Expansion for Site-Specific Click-PAINT Super-Resolution Microscopy. Angew Chem Int Ed Engl. 2016 Dec 23;55(52):16172-16176

Plasticity of an ultrafast interaction between nucleoporin and transport receptors, Cell, 2015 Oct 22;163(3):734-45

Continuous throughput and long-term observation of single-molecule FRET without immobilization. Nature Methods, Mar;11(3):297-300 (2014)

Application InstructionsPlease apply online through www.embl.org/jobs

Additional InformationEMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprise a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.

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